5 edition of Genetics of influenza viruses found in the catalog.
Includes bibliographies and indexes.
|Statement||edited by Peter Palese and David W. Kingsbury.|
|Contributions||Palese, Peter, 1944-, Kingsbury, David W.|
|LC Classifications||QR201.I6 G47 1983|
|The Physical Object|
|Pagination||xvi, 360 p. :|
|Number of Pages||360|
|LC Control Number||83016680|
Recommended composition of influenza virus vaccines for use in the - northern hemisphere influenza season; Antigenic and genetic characteristics of zoonotic influenza viruses and candidate vaccine viruses developed for potential use in human vaccines. Save 84% off the newsstand price! In the last week of March in , two children in Southern California came down with the flu. They were 9 and 10 years old, a girl and a boy, and though it was.
Genetic Variation Among Influenza Viruses documents the proceedings of ICN-UCLA symposium held in Salt Lake City, Utah, March The symposium brought together people from different disciplines working with the common objective of reducing the ravages of influenza and to expose them to the totality of the problem of Edition: 1. Influenza, commonly known as the flu, is an infectious disease of birds and was thought to be caused by comets, earthquakes, volcanoes, cosmic dust, the rising and setting of the sun, vapors arising from the air and ground, or a blast from the stars. Now we know that it is caused by an RNA virus of the family Orthomyxoviridae (the influenza viruses).
Antigenic shift, genetic alteration occurring in an infectious agent that causes a dramatic change in a protein called an antigen, which stimulates the production of antibodies by the immune systems of humans and other animals. Antigenic shift has been studied most extensively in influenza type A viruses, which experience this change about once every 10 years. This chapter provides background information on avian influenza viruses and the factors that have led to the emergence, spread and persistence of HPAI viruses. It uses experiences before and after the emergence of Asian-lineage H5N1 HPAI viruses as a guide. Avian influenza viruses Aquatic birds are the natural hosts of type A influenza viruses.
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The Use of Conditional Lethal Mutants 5 F. New Approaches in Influenza Virus Genetics. 6 1. The Biochemical Identification of Viral Gene Products in the Unambiguous Definition of Viral Inheritance 6 2.
Mapping of the Influenza Virus Genome by Correlative Physico-Chemical and Biological Techniques. Genome Sequencing. Influenza viruses are constantly changing, in fact all influenza viruses undergo genetic changes over time (for more information, see How the Flu Virus Can Change: “Drift” and “Shift”).An influenza virus’ genome consists of all genes that make up the virus.
Genetics of influenza viruses. Wien ; New York: Springer-Verlag, © (OCoLC) Online version: Genetics of influenza viruses. Wien ; New York: Springer-Verlag, © (OCoLC) Document Type: Book: All Authors / Contributors: Peter Palese; David W Kingsbury. Figure Genetic reassortment. (A) When a given cell is infected by two viral strains, hybrid viruses can be generated by exchanging their segmented genome, a mechanism called “genetic reassortment.” (B) Pigs can be infected by both avian and human influenza viruses, because the glycans in the upper respiratory tract express sialic acids with not only an α-2,3 linkage but also an α Influenza A viruses contain genomes composed of eight separate segments of negative-sense RNA.
Circulating human strains are notorious for their tendency to accumulate mutations from one year to the next and cause recurrent epidemics. However, the segmented nature of the genome also allows for the exchange of entire genes between different viral strains. The ability to manipulate influenza.
Influenza B viruses generally change more slowly in terms of their genetic and antigenic properties than influenza A viruses, especially influenza A(H3N2) viruses. Influenza surveillance data from recent years shows co-circulation of influenza B viruses from both lineages in the United States and around the world.
Each year in the USA, more thanpatients are admitted to hospitals because of influenza and there are approximat influenza-related deaths.
Of the three types of influenza virus-A, B and C-the A and B types can cause flu epidemics. Influenza A virus is. 19 hours ago Study unveils novel mechanism that allows viruses to produce unexpected proteins. Like a scene out of “Invasion of the Body Snatchers,” a virus infects a host and converts it into a factory for making more copies of researchers have shown that a large group of viruses, including the influenza viruses and other serious pathogens, steal genetic signals from their hosts to expand.
Genetic Variation Among Influenza Viruses documents the proceedings of ICN-UCLA symposium held in Salt Lake City, Utah, March The symposium brought together people from different disciplines working with the common objective of reducing the ravages of influenza and to expose them to the totality of the problem of influenza.
The Textbook of Influenza is a comprehensive resource covering all aspects of influenza, from the genetic and molecular biology of the virus through to clinical aspects of the disease and the latest drug developments and treatments.
This new edition has been completely revised and reflects the integration of disciplines concerning the emergence, evolution, pathogenesis and control of influenza. Characterization of five of the eight RNA segments of the influenza virus indicates that it was the common ancestor of both subsequent human and swine H1N1 lineages, and experiments testing models of virulence using reverse genetics approaches with influenza genes have begun in hopes of identifying genetic features that confer.
Genetic drifts are small changes in genetic material called point-mutations which can occur in a single virus strain. Genetic shifts are when the genetic material of different strains of influenza.
A group of Defense Department researchers has found genetic material from the notorious Spanish flu virus that killed at least 20 million people worldwide in the influenza.
Despite decades of surveillance and pharmaceutical and non-pharmaceutical interventions, seasonal influenza viruses continue to cause epidemics around the world each year. The key process underlying these recurrent epidemics is the evolution of the viruses to escape the immunity that is induced by p.
Influenza virus is an important human pathogen, frequently causing widespread disease and a significant loss of life. Much has been learned about the structure of the virus, its genetic variation, its mode of gene expression and replication, and its interaction with the host immu nologic system.
Two influenza B viruses (Victoria and Yamagata) cocirculate in humans and contribute to the estimated ,–, annual influenza-attributed deaths.
Here, we analysed influenza B genomic data to understand the causes of a recent surge in human influenza B infections. We found that evolution is acting differently on Yamagata and Victoria viruses and that this has led to the.
Influenza virus is one of the most changeable viruses known. There are two ways that influenza virus changes – these are called drift and shift. Drifting, or antigenic drift, is a gradual, continuous change that occurs when the virus makes small “mistakes” when copying its genetic information. Influenza A virus causes influenza in birds and some mammals, and is the only species of the genus Alphainfluenzavirus of the virus family Orthomyxoviridae.
Strains of all subtypes of influenza A virus have been isolated from wild birds, although disease is uncommon. Some isolates of influenza A virus cause severe disease both in domestic poultry and, rarely, in humans.
Influenza, acute viral infection of the upper or lower respiratory tract, marked by fever, chills, and a generalized feeling of malaise. Influenza is caused by viruses in the family Orthomyxoviridae.
Learn more about the classification of influenza viruses, influenza outbreaks, and influenza. “Influenza by Dr. Jeremy Brown vividly reminds us that the flu has been one of the great ravages of our time. Read this important and comprehensive book to learn what happened a century ago, and how we continue to try and overcome this ever-present and mutating killer.” —Sandeep Jauhar, New York Times bestselling author of Heart: A History.
Genetic reassortment plays a vital role in the evolution of the influenza virus and has historically been linked with the emergence of pandemic strains. Reassortment is believed to occur when a single host - typically swine - is simultaneously infected with multiple influenza strains.
The reassorted viral strains with novel gene combinations tend to easily evade the immune system in other host.However, in zoonotic transmission of SIV (both H3N2 and H1N2 subtypes) containing the matrix gene from the pandemic H1N1 virus was reported. These strains appeared to be able to spread more easily from pigs to people than other influenza viruses of swine.
Therefore, this multifaceted book has assumed greater significance.Human influenza is an acute respiratory infection primarily caused by viruses influenza A and influenza nza A viruses can be further classified into subtypes, such as A/H1N1 and A/, subtypes are denoted according to their hemagglutinin (H or HA) and neuraminidase (N or NA) genes, which as surface proteins, act as the primary targets for the humoral immune response.